Review Questions
Post-translational modifications of proteins can affect which of the following?
- protein function
- transcriptional regulation
- chromatin modification
- all of the above
Hint:
A
A scientist mutates eIF-2 to eliminate its GTP hydrolysis capability. How would this mutated form of eIF-2 alter translation?
- Initiation factors would not be able to bind to mRNA.
- The large ribosomal subunit would not be able to interact with mRNA transcripts.
- tRNAi-Met would not scan mRNA transcripts for the start codon.
- eIF-2 would not be able to interact with the small ribosomal subunit.
Hint:
B