By the end of this section, you will be able to do the following:
Describe how changes to gene expression can cause cancer
Explain how changes to gene expression at different levels can disrupt the cell cycle
Discuss how understanding regulation of gene expression can lead to better drug design
By the end of this section, you will be able to do the following:
Explain how chromatin remodeling controls transcriptional access
Describe how access to DNA is controlled by histone modification
Describe how DNA methylation is related to epigenetic gene changes
By the end of this section, you will be able to do the following:
Understand RNA splicing and explain its role in regulating gene expression
Describe the importance of RNA stability in gene regulation
By the end of this section, you will be able to do the following:
Discuss the role of transcription factors in gene regulation
Explain how enhancers and repressors regulate gene expression
By the end of this section, you will be able to do the following:
Understand the process of translation and discuss its key factors
Describe how the initiation complex controls translation
Explain the different ways in which the post-translational control of gene expression takes place
By the end of this section, you will be able to do the following:
Describe the steps involved in prokaryotic gene regulation
Explain the roles of activators, inducers, and repressors in gene regulation
By the end of this section, you will be able to do the following:
Discuss why every cell does not express all of its genes all of the time
Describe how prokaryotic gene regulation occurs at the transcriptional level
Discuss how eukaryotic gene regulation occurs at the epigenetic, transcriptional, post-transcriptional, translational, and post-translational levels
By the end of this section, you will be able to do the following:
List the steps in eukaryotic transcription
Discuss the role of RNA polymerases in transcription
Compare and contrast the three RNA polymerases
Explain the significance of transcription factors
By the end of this section, you will be able to do the following:
List the different steps in prokaryotic transcription
Discuss the role of promoters in prokaryotic transcription
Describe how and when transcription is terminated
By the end of this section, you will be able to do the following:
Describe the different steps in RNA processing
Understand the significance of exons, introns, and splicing for mRNAs
Explain how tRNAs and rRNAs are processed
By the end of this section, you will be able to do the following:
Describe the different steps in protein synthesis
Discuss the role of ribosomes in protein synthesis
By the end of this section, you will be able to do the following:
Explain the “central dogma” of DNA-protein synthesis
Describe the genetic code and how the nucleotide sequence prescribes the amino acid and the protein sequence
By the end of this section, you will be able to do the following:
Explain that meiosis and sexual reproduction are highly evolved traits
Identify variation among offspring as a potential evolutionary advantage of sexual reproduction
Describe the three different life-cycle types among sexually reproducing multicellular organisms.
By the end of this section, you will be able to do the following:
Describe the behavior of chromosomes during meiosis, and the differences between the first and second meiotic divisions
Describe the cellular events that take place during meiosis
Explain the differences between meiosis and mitosis
Explain the mechanisms within the meiotic process that produce genetic variation among the haploid gametes
By the end of this section, you will be able to do the following:
Explain the relationship between genotypes and phenotypes in dominant and recessive gene systems
Develop a Punnett square to calculate the expected proportions of genotypes and phenotypes in a monohybrid cross
Explain the purpose and methods of a test cross
Identify non-Mendelian inheritance patterns such as incomplete dominance, codominance, recessive lethals, multiple alleles, and sex linkage
By the end of this section, you will be able to do the following:
Explain Mendel’s law of segregation and independent assortment in terms of genetics and the events of meiosis
Use the forked-line method and the probability rules to calculate the probability of genotypes and phenotypes from multiple gene crosses
Explain the effect of linkage and recombination on gamete genotypes
Explain the phenotypic outcomes of epistatic effects between genes
