An infectious disease specialist at Hackensack University Medical Center in New Jersey, Dr. Bindu Balani treated the state's first confirmed COVID-19 patient in March 2020. In this episode, Bindu shares her experiences on the front line of the battle to identify, treat, and stem the subsequent surge of COVID-19 cases. From this unique vantage point, we learn how all units of the hospital mobilized and adapted to protect and serve the patients in their care. A new virtual interview series from LabXchange at Harvard University, the Xchange showcases the diverse roles, projects, and initiatives that make up the intersecting fields of science, education, and health. Hosted by LabXchange Faculty Director Robert Lue, our first season features a range of perspectives on the impact of COVID-19.

This pathway explores how structural and molecular evidence can be used to determine relationships between plant species.

This pathway provides an overview of the four classes of biological molecules (lipids, carbohydrages, proteins and nucleotides) and how they are assembled.

This pathway introduces how DNA can be manipulated using different molecular tools and techniques. For a deeper look at this topic, we recommend the pathway Biotechnology and Genomics from the OpenStax textbook Biology for AP® Courses.

This pathway provides and introduction to some of the systems of the body and the concept of homeostasis.

This pathway shows how LabXchange can help build scientific literacy skills to help you engage with the science happening around you.

This pathway highlights some of the features and content types on LabXchange that allow researchers and those interested in research to connect and share their experiences.

This pathway describes how DNA ligase, a key enzyme in DNA replication, is used in gene cloning to create a recombinant plasmid. This pathway supports ABE lab 3: Building a Recombinant Plasmid.

This pathway explains how restriction enzymes are used in gene cloning to obtain the DNA pieces that will create a recombinant plasmid. This pathway supports ABE labs 2, 2a, 3, 4, and 4a.

Guest lecture recorded July 28, 2020 with Professor Richard Sherwood, Assistant Professor of Medicine at Brigham and Women’s Hospital. Molecular cloning is essential to research in genetics and cell biology. In this webinar, Dr. Sherwood shares how his lab uses molecular cloning to power their work in genetics and CRISPR/Cas9 genome editing.

The CRISPR-Cas9 editing tool causes a double-stranded break in target DNA that immediately triggers cellular DNA repair mechanisms to fix this dangerous situation. These repair mechanisms can be taken advantage of by scientists to disrupt or precisely change genes.

This video shows how the Cas9-gRNA complex cleaves DNA visualized in real-time using atomic force microscopy. Astonishingly, single molecules of Cas9 and DNA can be made visible with this technology.

This video illustrates how to test guide RNAs to facilitate the cleaving of a macrophage gene in vitro.

Guest lecture recorded July 30, 2020 by Dr. Jessica Whited, Assistant Professor of Stem Cell and Regenerative Biology at Harvard University. Dr. Whited studies limb regeneration in axolotl salamanders, with the ultimate goal of discovering how to regenerate limbs in patients. In this webinar, Dr. Whited discusses how her work involves using Cas9-mediated gene drives to generate axolotls with the desired genetic backgrounds.

This scrollable introduces CRISPR's native role as a bacterial defense system. The gene editing tool CRISPR-Cas9 derives from it.

In this episode on Building Resilient Ecosystems for Education, Dr. Caroline Levander, who views university campuses as places of passion and dynamism, will provide insight into her roles as a university leader and scholar, and discuss the nuts and bolts of building community in higher education. A new virtual interview series from LabXchange at Harvard University, The Xchange showcases the diverse roles, projects, and initiatives that make up the intersecting fields of science, education, and health. Hosted by LabXchange Faculty Director Robert Lue, our first season features a range of perspectives on the impact of COVID-19.

Join us for a talk on CRISPR by Jessica Whited, Assistant Professor of Stem Cell and Regenerative Biology at Harvard University. Dr. Whited studies limb regeneration in axolotl salamanders, with the ultimate goal of discovering how to regenerate limbs in patients. Her work involves using Cas9-mediated gene drives to generate axolotls with the desired genetic backgrounds. Recorded live: July 30th, 1 – 2:30 pm EDT.

Progress in science comes from sharing ideas and expanding on the work of others. LabXchange helps preserve the research of young scientists through our case study asset, which makes it easy to share and communicate research with others. By constructing a case study, students learn to communicate science in a concise and accessible way and model the formats used by professional scientists.

This pathway provides an introduction to cellular mechanisms of communication, highlighting one of the primary mechanisms: signal transduction pathways. For a deeper look at this topic, we recommend the pathway Cell Communication from the OpenStax textbook Biology for AP® Courses.

This pathway provides an introduction to the cell cycle and how its regulation is important to normal cell division. Cancer is often caused by unregulated cell division. For a deeper look at this topic, we recommend the pathway Cell Reproduction from the OpenStax textbook Biology for AP® Courses.