American Government is designed to meet the scope and sequence requirements of the single-semester American government course. This title includes innovative features designed to enhance student learning, including Insider Perspective features and a Get Connected Module that shows students how they can get engaged in the political process. The book provides an important opportunity for students to learn the core concepts of American government and understand how those concepts apply to their lives and the world around them. American Government includes updated information on the 2016 presidential election.Senior Contributing AuthorsGlen Krutz (Content Lead), University of OklahomaSylvie Waskiewicz, PhD (Lead Editor)

Students learn about various crystals, such as kidney stones, within the human body. They also learn about how crystals grow and ways to inhibit their growth. They also learn how researchers such as chemical engineers design drugs with the intent to inhibit crystal growth for medical treatment purposes and the factors they face when attempting to implement their designs. A day before presenting this lesson to students, conduct the associated activity, Rock Candy Your Body.

This video illustrates how to test guide RNAs to facilitate the cleaving of a macrophage gene in vitro.

This pathway introduces the design of guide RNAs to disrupt a macrophage gene with the gene editing tool CRISPR-Cas9. Afterwards, a DNA cleavage assay is created to test how well the designed gRNAs work.

Students are challenged to think as biomedical engineers and brainstorm ways to administer medication to a patient who is unable to swallow. They learn about the advantages and disadvantages of current drug delivery methods—oral, injection, topical, inhalation and suppository—and pharmaceutical design considerations, including toxicity, efficacy, size, solubility/bioavailability and drug release duration. They apply their prior knowledge about human anatomy, the circulatory system, polymers, crystals and stoichiometry to real-world biomedical applications. A Microsoft® PowerPoint® presentation and worksheets are provided. This lesson prepares students for the associated activity in which they create and test large-size drug encapsulation prototypes to provide the desired delayed release and duration timing.

Students learn how crystallization and inhibition occur by examining calcium oxalate crystals with and without inhibitors that are capable of altering crystallization. Kidney stones are composed of calcium oxalate crystals, and engineers and doctors experiment with these crystals to determine how growth is affected when a potential drug is introduced. Students play the role of engineers by trying to determine which inhibitor would be the best for blocking crystallization.

Students see and learn how crystallization and inhibition occur by making sugar crystals with and without additives in a supersaturation solution, testing to see how the additives may alter crystallization, such as by improving crystal growth by more or larger crystals. After three days, students analyze the differences between the control crystals and those grown with additives, researching and attempting to deduce why certain additives blocked crystallization, showed no change or improved growth. Students relate what they learn from the rock candy experimentation to engineering drug researchers who design medicines for targeted purposes in the human body. Conduct the first half of this activity one day before presenting the associated lesson, Body Full of Crystals. Then conduct the second half of the activity.