Students learn about the biomedical use of nanoparticles in the detection and treatment of cancer, including the use of quantum dots and lasers that heat-activate nanoparticles. They also learn about electrophoresis a laboratory procedure that uses an electric field to move tiny particles through a channel in order to separate them by size. They complete an online virtual mini-lab, with accompanying worksheet, to better understand gel electrophoresis. This prepares them for the associated activity to write draft research proposals to use nanoparticles to protect against, detect or treat skin cancer.

Through this unit, students act as engineers who are given the challenge to design laparoscopic surgical tools. After learning about human anatomy and physiology of the abdominopelvic cavity, especially as it applies to laparoscopic surgery, students learn about the mechanics of elastic solids, which is the most basic level of material behavior. Then, they explore the world of fluids and learn how fluids react to forces. Next, they combine their understanding of the mechanics of solids and fluids to understand viscoelastic materials, such as those found in the human body. Finally, they learn about tissue mechanics, including how collagen, elastin and proteoglycans give body tissues their unique characteristics. In the culminating hands-on activity, student teams design their own prototypes of laparoscopic surgical robots remotely controlled, camera-toting devices that must fit through small incisions, inspect organs and tissue for disease, obtain biopsies, and monitor via ongoing wireless image-taking. They use a (homemade) synthetic abdominal cavity simulator to test and iterate the prototype devices.

Students are introduced to prosthetics history, purpose and benefits, main components, main types, materials, control methods, modern examples including modern materials used to make replacement body parts and the engineering design considerations to develop prostheses. They learn how engineers and medical doctors work together to improve the lives of people with amputations and the challenges faced when designing new prostheses with functional and cosmetic criteria and constraints. A PowerPoint(TM) presentation and two worksheets are provided.

Students follow the steps of the engineering design process while learning more about assistive devices and biomedical engineering applied to basic structural engineering concepts. Their engineering challenge is to design, build and test small-scale portable wheelchair ramp prototypes for fictional clients. They identify suitable materials and demonstrate two methods of representing design solutions (scale drawings and simple models or classroom prototypes). Students test the ramp prototypes using a weighted bucket; successful prototypes meet all the student-generated design requirements, including support of a predetermined weight.

This lesson culminates the unit with the Go Public phase of the legacy cycle. In the associated activity, students depict a tumor amidst healthy body tissue using a Microsoft Excel® graph. In addition, students design a brochure for both patients and doctors advertising a new form of painless yet reliable breast cancer detection. Together, the in-class activity and the take-home assignment function as an assessment of what students have learned throughout the unit.

Student teams investigate biomedical engineering and the technology of prosthetics. Students create a model prosthetic lower leg using various materials. Each team demonstrate its prosthesis' strength and consider its pros and cons, giving insight into the characteristics and materials biomedical engineers consider in designing artificial limbs.

Students design and build prototypes for protective eyewear. They choose different activities or sports that require protective eyewear and design a device for that particular use. Students learn about the many ways in which the eyes can be damaged and how engineers incorporate different features and materials into eyewear designs to best protect the eyes.

Students learn about how biomedical engineers aid doctors in repairing severely broken bones. They learn about using pins, plates, rods and screws to repair fractures. They do this by designing, creating and testing their own prototype devices to repair broken turkey bones.

Students use their knowledge about how healthy heart valves function to design, construct and implant prototype replacement mitral valves for hypothetical patients' hearts. Building on what they learned in the associated lesson about artificial heart valves, combined with the testing and scoring of their prototype heart valve designs in this activity, students discover the pros and cons of different types of artificial heart valves based on materials, surgery requirements, and lifespan.

Students participate in a variety of activities modeling different disabilities. They gain a better understanding of physical limitations while performing tasks at workstations without the use of their thumbs (taped down), impaired vision (various glasses) and impaired mobility (using crutches and wheelchairs). After discussing their experiences, they work in teams to create or improve on an adaptive device. Like biomedical engineers, students are challenged to design with the purpose of helping make a particular task easier for another person.

Students learn how engineering design is applied to solve healthcare problems by using an engineering tool called simulation. While engineering design is commonly used to study and design everything from bridges, factories, airports to space shuttles, the use of engineering design to study healthcare administration and delivery is a relatively new concept.

Towards finding a solution to the unit's Grand Challenge Question about using nanoparticles to detect, treat and protect against skin cancer, students continue the research phase in order to answer the next research questions: What is the structure and function of skin? How does UV radiation affect the chemical reactions that go on within the skin? After seeing an ultraviolet-sensitive bead change color and learning how they work, students learn about skin anatomy and the effects of ultraviolet radiation on human skin, pollution's damaging effect on the ozone layer that can lead to increases in skin cancer, the UV index, types of skin cancer, ABCDEs of mole and lesion evaluation, and the sun protection factor (SPF) rating system for sunscreens. This prepares students to conduct the associated activity, in which they design quality-control experiments to test SPF substances.

Students develop a persuasive peer-to-peer case against smoking, with the goal to understand how language usage can influence perception, attitudes and behavior.

Students learn about the strength of bones and methods of helping to mend fractured bones. During a class demonstration, a chicken bone is broken by applying a load until it reaches a point of failure (fracture). Then, working as biomedical engineers, students teams design their own splint or cast to help repair a fractured bone, learning about the strength of materials used.

This unit focuses on teaching students about the many aspects of biomedical engineering (BME). Students come to see that BME is a broad field that relies on concepts from many engineering disciplines. They also begin to understand some of the special considerations that must be made when dealing with the human body. Activities and class discussions encourage students to think as engineers to come up with their own solutions to some of medical challenges that have been solved throughout the history of BME. Class time iincludes brainstorming and presenting ideas to the class for discussion. Specific activities include examination of the material properties and functions of surgical instruments and prosthetics, a simulation of the training experience of a surgical resident, and an investigation of the properties of fluid flow in vascular tissue.

Students are introduced to the unit challenge discovering a new way to assess a person's risk of breast cancer. Solving this challenge requires knowledge of refraction and the properties of light. After being introduced to the challenge question, students generate ideas related to solving the challenge, and then read a short online article on optical biosensors that guides their research towards solving the problem.

Through four lessons and three hands-on activities, students learn the concepts of refraction and interference in order to solve an engineering challenge: "In 2013, actress Angelina Jolie underwent a double mastectomy, not because she had been diagnosed with breast cancer, but merely to lower her cancer risk. But what if she never inherited the gene(s) that are linked to breast cancer and endured surgery unnecessarily? Can we create a new method of assessing people's genetic risks of breast cancer that is both efficient and cost-effective?" While pursuing a solution to this challenge, students learn about some high-tech materials and delve into the properties of light, including the equations of refraction (index of refraction, Snell's law). Students ultimately propose a method to detect cancer-causing genes by applying the refraction of light in a porous film in the form of an optical biosensor. Investigating this challenge question through this unit is designed for an honors or AP level physics class, although it could be modified for conceptual physics.

Students learn about glaucoma its causes, how it affects individuals and how biomedical engineers can identify factors that trigger or cause this eye disease, specifically the increase of pressure in the eye. Students also learn how RFID technologies transfer energy through waves and how engineers apply their scientific understanding of waves, energy and sensors to develop devices that measure the pressure in the eyes of people with glaucoma. Students conclude by sketching their own designs for a pressure-measuring eye device, preparing them to conduct the associated activity in which they revise, prototype and evaluate their device designs made tangible with a 3D printer.

This unit on nanoparticles engages students with a hypothetical Grand Challenge Question that asks about the skin cancer risk for someone living in Australia, given the local UV index and the condition of the region's ozone layer. The question asks how nanoparticles might be used to help detect, treat and protect people from skin cancer. Through three lessons, students learn about the science of electromagnetic radiation and energy waves, human skin and its response to ultraviolet radiation, and the state of medical nanotechnology related to skin cancer. Through three hands-on activities, students perform flame tests to become familiar with the transfer of energy in quantum form, design and conduct their own quality-control experiments to test sun protection factors (SPFs), and write nanotechnology grant proposals.

Students are presented with a biomedical engineering challenge: Breast cancer is the second-leading cause of cancer-related death among women and the American Cancer Society says mammography is the best early-detection tool available. Despite this, many women choose not to have them; of all American women at or over age 40, only 54.9% have had a mammogram within the past year. One reason women skip annual mammograms is pain, with 90% reporting discomfort. Is there a way to detect the presence of tumors that is not as painful as mammography but more reliable and quantifiable than breast self-exams or clinical breast exams? This three lesson/three activity unit is designed for first-year accelerated or AP physics classes. It provide hands-on activities to teach the concepts of stress, strain and Hooke's law, which students apply to solve the challenge problem.