Students act as if they are biological engineers following the steps of the engineering design process to design and create protein models to replace the defective proteins in a child’s body. Jumping off from a basic understanding of DNA and its transcription and translation processes, students learn about the many different proteins types and what happens if protein mutations occur. Then they focus on structural, transport and defense proteins during three challenges posed by the R&D; bio-engineering hypothetical scenario. Using common classroom supplies such as paper, tape and craft sticks, student pairs design, sketch, build, test and improve their own protein models to meet specific functional requirements: to strengthen bones (collagen), to capture oxygen molecules (hemoglobin) and to capture bacteria (antibody). By designing and testing physical models to accomplish certain functional requirements, students come to understand the relationship between protein structure and function. They graph and analyze the class data, then share and compare results across all teams to determine which models were the most successful. Includes a quiz, three worksheets and a reference sheet.

General transcription factors, activators, and repressors interact to regulate the transcription of eukaryotic DNA into RNA. [2:05]

Biology 2e is designed to cover the scope and sequence requirements of a typical two-semester biology course for science majors. The text provides comprehensive coverage of foundational research and core biology concepts through an evolutionary lens. Biology includes rich features that engage students in scientific inquiry, highlight careers in the biological sciences, and offer everyday applications. The book also includes various types of practice and homework questions that help students understand—and apply—key concepts. The 2nd edition has been revised to incorporate clearer, more current, and more dynamic explanations, while maintaining the same organization as the first edition. Art and illustrations have been substantially improved, and the textbook features additional assessments and related resources.

By the end of this section, you will be able to do the following:

Discuss the role of transcription factors in gene regulation
Explain how enhancers and repressors regulate gene expression

By the end of this section, you will be able to do the following:

Describe nucleic acids' structure and define the two types of nucleic acids
Explain DNA's structure and role
Explain RNA's structure and roles

This pathway explores the processes of transcription and translation that allow cells to produce proteins from DNA.

This pathway includes an introduction to how genetic information is replicated and expressed to form proteins. For a deeper look at this topic, we recommend the pathways DNA Structure and Function and Genes and Proteins from the OpenStax textbook Biology for AP® Courses.

See how DNA is copied through a process called replication. Learn how information in DNA can be used to make a protein. [15:24]

Khan Academy learning modules include a Community space where users can ask questions and seek help from community members. Educators should consult with their Technology administrators to determine the use of Khan Academy learning modules in their classroom. Please review materials from external sites before sharing with students.

Learn how DNA is copied during replication, and find out how information in DNA can be used to make a protein. [15:24]

Khan Academy learning modules include a Community space where users can ask questions and seek help from community members. Educators should consult with their Technology administrators to determine the use of Khan Academy learning modules in their classroom. Please review materials from external sites before sharing with students.

See how DNA is copied by replication, and learn how information in DNA can be used to make a protein. [15:23]

Khan Academy learning modules include a Community space where users can ask questions and seek help from community members. Educators should consult with their Technology administrators to determine the use of Khan Academy learning modules in their classroom. Please review materials from external sites before sharing with students.

Some viruses use RNA and reverse transcription to function. This article covers the scientists and experiments that made this discovery. Article includes animations, pictures, video, biographical information, and quiz questions that are accessed by clicking on buttons along the bottom of the page.

This video explains the different ways the gene editing complex CRISPR-Cas9 is delivered into cells.

Learning about transcription and translation can be difficult but this animation helps make the processes less confusing. The animation is interactive and it also covers the overall importance of proteins.

Do your students struggle to understand the “central dogma” of biology? Are you looking for innovative teaching techniques? This unit is an integrated art and science project to teach transcription and translation, which is also known as “central dogma”. This process explains how sequences of DNA are interpreted by organelles in the cell and are expressed as specific proteins. It is a core idea in understanding molecular genetics. Students will create a three-paneled work of art that models the process of transcription and translation. Explicit instructions make this unit accessible to science teachers. This unit features 4 lessons and 15 files. Lessons are aligned to NGSS.

This pathway will help learners better understand the critical role that bacterial cells play as protein production factories in the process of gene cloning. The processes of binary fission, transcription and translation are all essential for this role and are explored in detail here. For those using this pathway as part of the Amgen Biotech Experience, this pathway is a good companion to ABE Lab 5.

Students learn how engineers apply their understanding of DNA to manipulate specific genes to produce desired traits, and how engineers have used this practice to address current problems facing humanity. They learn what genetic engineering means and examples of its applications, as well as moral and ethical problems related to its implementation. Students fill out a flow chart to list the methods to modify genes to create GMOs and example applications of bacteria, plant and animal GMOs.